8636. Sodium Lauryl Sulfate

Nomenclature

CAS number: 151-21-3
Sulfuric acid monododecyl ester sodium salt (1:1); sodium dodecyl sulfate; SDS; Irium.
C12H25NaO4S; mol wt 288.38.
C 49.98%, H 8.74%, Na 7.97%, O 22.19%, S 11.12%.
CH3(CH2)10CH2OSO3Na.

Description and references

Anionic detergent prepd by sulfation of lauryl alcohol, followed by neutralization with sodium carbonate: A. Lottermoser, F. Stoll, Kolloid-Z. 63, 50 (1933). Surfactant properties: J. Powney, C. C. Addison, Trans. Faraday Soc. 33, 1244 (1937); E. E. Dreger et al., Ind. Eng. Chem. 36, 610 (1944). Use in electrophoretic sepn and mol wt estimation of proteins: A. L. Shapiro et al., Biochem. Biophys. Res. Commun. 28, 815 (1967); K. Weber, M. Osborn, J. Biol. Chem. 244, 4406 (1969); of glycopolypeptides: B. S. Leach et al., Biochemistry 19, 5734 (1980). Toxicity study: A. I. T. Walker et al., Food Cosmet. Toxicol. 5, 763 (1967). Review of toxicology: Ch. Gloxhuber, Arch. Toxicol. 32, 245-270 (1974).

Properties

White or cream-colored crystals, flakes, or powder. mp 204-207°. Faint odor of fatty substances. Smooth feel. Neutral reaction. One gram dissolves in 10 ml water, giving an opalescent soln. Lowers the surface tension of aq solns. Emulsifies fats. LD50 orally in rats: 1288 mg/kg (Walker).

Use

Wetting agent, detergent, esp in the textile industry. Electrophoretic separation of proteins and lipids. Ingredient of toothpastes.