8649. Sodium Nitroprusside

Nomenclature

CAS number: 14402-89-2
Sodium (OC-6-22)-pentakis(cyano-κC)nitrosylferrate(2) (2:1); sodium nitrosylpentacyanoferrate(III); sodium nitroferricyanide; sodium nitroprussiate.
C5FeN6Na2O; mol wt 261.92.
C 22.93%, Fe 21.32%, N 32.09%, Na 17.55%, O 6.11%.
Na2[Fe(CN)5NO].

Description and references

Peripheral vasodilator. Prepn: L. Playfair, Proc. R. Soc. London 5, 846 (1849). Crystal structure: D. Schaniel et al., Phys. Rev. B 68, 104108 (2003); idem et al., ibid. 71, 174112 (2005). Pharmacology: Fernandez et al., Arch. Inst. Farmacol. Exp. Madrid 23, 1-51 (1971). Review: I. H. Tuzel, J. Clin. Pharmacol. 14, 494-503 (1974). Review of pharmacology, toxicology and therapeutic uses: J. H. Tinker, J. D. Michenfelder, Anesthesiology 45, 340 (1976). Comprehensive description: R. Rucki, Anal. Profiles Drug Subs. 6, 487-513 (1977); A. Bult et al., ibid. 15, 781-792 (1986). Clinical trial in critically ill patients with heart failure: U. N. Khot et al., N. Engl. J. Med. 348, 1756 (2003). Review of therapeutic uses: J. A. Friederich, J. F. Butterworth, Anesth. Analg. 81, 152-162 (1995).

Derivative

Dihydrate.

Nomenclature

CAS number: 13755-38-9
Nipride (Roche); Nipruss (Schwarz); Nitropress (Hospira).
C5FeN6Na2O.2H2O; mol wt 297.95.
C 20.16%, Fe 18.74%, N 28.21%, Na 15.43%, O 16.11%, H 1.35%.

Properties

Ruby-red, practically odorless, transparent crystals. Sol in ≈2.3 parts water, slightly in alcohol. Slowly dec in aq soln.

Use

Reagent for the detection of many organic compds, e.g., acetone, aldehydes, also of alkali sulfides, zinc, SO2.

Therapeutic Category

Antihypertensive.

Therapeutic Category (Veterinary)

Antihypertensive.

Keywords

Antihypertensive