8751. Spiperone

Nomenclature

CAS number: 749-02-0
8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; 8-[3-(p-fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; 4-phenyl-8-[3-(4-fluorobenzoyl)propyl]-1-oxo-2,4,8-triazaspiro[4.5]decane; Spiropitan (Janssen).
C23H26FN3O2; mol wt 395.47.
C 69.85%, H 6.63%, F 4.80%, N 10.63%, O 8.09%.

Description and references

Prepn: Janssen, US 3155669; US 3155670 and US 3161644 (all 1964 to Janssen).

Chemical structure

Properties

Crystals, mp 190-193.6°.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Butyrophenones