8809. Stepronin

Nomenclature

CAS number: 72324-18-6
N-[1-Oxo-2-[(2-thienylcarbonyl)thio]propyl]glycine; 2-(α-thenoylthio)propionylglycine; N-(2-mercaptopropionyl)glycine 2-thiophenecarboxylate (ester); TTPG; prostenoglycine; Tiase (Mediolanum).
C10H11NO4S2; mol wt 273.33.
C 43.94%, H 4.06%, N 5.12%, O 23.41%, S 23.46%.

Description and references

Prepn, properties and toxicology: F. Bolasco, BE 875186; eidem, US 4242354 (1979, 1980 to Mediolanum Farmaceutici). Clinical trials in bronchitis: M. Lingetti et al., Int. J. Clin. Pharmacol. Res. 1, 273 (1981); F. Dotta et al., Clin. Ter. 105, 307 (1983); G. C. Morandini et al., Curr. Ther. Res. 35, 783 (1984). Effect on human lung mucus: M. C. Morale et al., Int. J. Tissue React. 5, 231 (1983).

Chemical structure

Properties

Colorless crystals from acetonitrile, mp 168-170°. uv max: 292 nm. LD50 in mice (mg/kg): >2500 orally, >1250 i.v.; in rats (mg/kg): >2500 orally, 1801 i.m. (Bolasco).

Derivative

Lysine salt.

Nomenclature

CAS number: 113790-28-6
Masor (Formenti); Mucodil (Valeas).

Derivative

Sodium salt.

Nomenclature

CAS number: 78126-10-0
Broncoplus (Sigma-Tau); Tioten (Mediolanum).
C10H10NNaO4S2; mol wt 295.31.
C 40.67%, H 3.41%, N 4.74%, Na 7.78%, O 21.67%, S 21.72%.

Therapeutic Category

Mucolytic.

Keywords

Mucolytic