8985. Sulmazole

Nomenclature

CAS number: 73384-60-8
2-[2-Methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine; AR-L 115BS; Vardax (Thomae).
C14H13N3O2S; mol wt 287.34.
C 58.52%, H 4.56%, N 14.62%, O 11.14%, S 11.16%.

Description and references

Orally active non-glycoside, non-adrenergic inotropic agent. Prepn: NL 7401254; E. Kutler et al., US 3985891 (1974, 1976 both to Thomae). Toxicity study: W. Diederen, R. Kadatz, Arzneim.-Forsch. 31, 141 (1981). Series of articles on pharmacology, pharmacokinetics, metabolism, clinical studies: ibid. 129-278. Brief review of pharmacology: H. Koch, Pharm. Int. 3, 5 (1982).

Chemical structure

Properties

Solid, mp 203-205°. LD50 in albino mice (mg/kg): 560 orally; 163 i.v. (Diederen, Kadatz).

Therapeutic Category

Cardiotonic.

Keywords

Cardiotonic