Orally active heparinoid prepared from porcine intestinal mucosa. Mixture of 80% electrophoretically fast moving heparin and 20% dermatan sulfate; average mol wt <8000. Preparative method: P. Bianchini, DE 2426586; idem, US 3936351 (1975, 1976 both to Opocrin). Review of pharmacology: F. A. Ofosu, Semin. Thromb. Hemostasis 24, 127-138 (1998); J. Harenberg, Med. Res. Rev. 18, 1-20 (1998). Effect on albuminuria in diabetic patients: J. Skrha et al., Diabetes Res. Clin. Pract. 38, 25 (1997). Clinical trial in venous leg ulcers: S. Coccheri et al., Thromb. Haemostasis 87, 947 (2002); in deep venous thrombosis: B. M. Errichi et al., Angiology 55, 243 (2004); in diabetic nephropathy: A. Achour et al., J. Nephrol. 18, 568 (2005).
Antithrombotic; in treatment of chronic leg ulcers and diabetic nephropathy.
Antithrombotic