8994. Sultopride
Nomenclature
CAS number: 53583-79-2
N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide; N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-o-anisamide. C17H26N2O4S; mol wt 354.46.
C 57.60%, H 7.39%, N 7.90%, O 18.05%, S 9.05%.
Description and references
Dopamine D2-receptor antagonist. Prepn: C. S. Miller et al., FR M 5916; see also: G. Bulteau et al., US 3975434 (1966, 1976 both to Soc. Etudes Sci. Ind. l'Ile-de-France). Pharmacology: C. Lavelle, J. Margarit, J. Pharmacol. 5, Suppl. 2, 58 (1974); B. Bruguerolle et al., ibid. 12, 27 (1981). Clinical trial in psychosis: D. Morel, Sem. Hop. 59, 2337 (1983). GC determn in serum: A. Kamizono et al., J. Chromatogr. 567, 113 (1991). Pharmacokinetics of enantiomers: idem et al., Biol. Pharm. Bull. 16, 1121 (1993).
Derivative
Hydrochloride.Nomenclature
CAS number: 23694-17-9
LIN-1418; Barnetil (Delagrange); Barnotil (Vita). C17H26N2O4S.HCl; mol wt 390.93.
C 52.23%, H 6.96%, N 7.17%, O 16.37%, S 8.20%, Cl 9.07%.
Properties
Crystals from methyl ethyl ketone, mp 181-182° (Miller); also reported as crystals from ethanol, mp 190° (Bulteau).Therapeutic Category
Antipsychotic.
Keywords
Antipsychotic; Benzamides; Dopamine Receptor Antagonist