8995. Sultosilic Acid

Nomenclature

CAS number: 57775-26-5
2-Hydroxy-5-[[(4-methylphenyl)sulfonyl]oxy]benzenesulfonic acid; 2-hydroxy-5-tosyloxybenzenesulfonic acid; 2,5-dihydroxybenzenesulfonic acid 5-p-toluenesulfonate.
C13H12O7S2; mol wt 344.36.
C 45.34%, H 3.51%, O 32.52%, S 18.62%.

Description and references

Prepn: NL 7305916 (1973 to Lab. del Esteve); J. Esteve et al., Eur. J. Med. Chem. 11, 43 (1976); of piperazine salt: A. Esteve-Subirana, US 3954767 (1976). Toxicology: L. Rodriguez et al., Arch. Farmacol. Toxicol. 5, 281 (1979). Metabolism: S. G. Wood et al., Xenobiotica 12, 165 (1982). Clinical evaluation: H. Vinazzer, J. C. Farine, Atherosclerosis 49, 109 (1983). HPLC determn and pharmacokinetics: R. Roser et al., Eur. J. Drug Metab. Pharmacokinet. 11, 1 (1986).

Chemical structure

Derivative

Piperazine salt.

Nomenclature

CAS number: 57775-27-6
Diethylenediamine sultosylate; piperazine sultosylate; A-585; Mimedran (Esteve).
C13H12O7S2.C4H10N2; mol wt 430.50.
C 47.43%, H 5.15%, O 26.02%, S 14.90%, N 6.51%.

Properties

Crystals from ethanol, mp 174°. LD50 i.p. in beagles, male rats, female rats: 605, 833.6, 1272 mg/kg; orally in rats: >11 g/kg (Rodriguez).

Therapeutic Category

Antilipemic.

Keywords

Antilipemic