9013. Synhexyl

Nomenclature

CAS number: 117-51-1
3-Hexyl-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol; 1-hydroxy-3-hexyl-6,6,9-trimethyl-7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyran; parahexyl; pyrahexyl.
C22H32O2; mol wt 328.49.
C 80.44%, H 9.82%, O 9.74%.

Description and references

Psychotomimetic synthetic analog of the tetrahydrocannabinols, q.v. Prepn: Adams et al., J. Am. Chem. Soc. 63, 1971 (1941); Adams, US 2419935 (1947); Hughes et al., US 3576887 (1971 to Am. Home Products). Comparison of physiological effects with those of tetrahydrocannabinol: Hollister et al., Clin. Pharmacol. Ther. 9, 783 (1968). Physical constants: Farmilo et al., Bull. Narc. 6, 7 (1954). Toxicity data: Loewe, J. Pharmacol. Exp. Ther. 88, 154 (1946).

Chemical structure

Properties

Liquid, bp1.0 190-192°; nD20 1.5504. uv and ir spectra: Bull. Narc. 6, 27 (1954); 7, 42 (1955). LD50 in mice, dogs, rabbits (mg/kg): 170, 223, 143 i.v. (Loewe).

Note

This is a controlled substance (hallucinogen): 21 CFR, 1308.11.