9022. Tacalcitol
Nomenclature
CAS number: 57333-96-7
(1α,3β,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol; 1α,24(R)-dihydroxycholecalciferol; 1α,24R-dihydroxyvitamin D3; TV-02; Bonealfa (Teijin); Curatoderm (Merck KGaA). C27H44O3; mol wt 416.64.
C 77.83%, H 10.64%, O 11.52%.
Description and references
Bioactive, synthetic vitamin D3 analog; exhibits antiproliferative effect on keratinocytes. Prepn: T. Takeshita et al., DE 2526981; eidem, US 4022891 (1976, 1977 both to Teijin); M. Morisaki et al., J. Chem. Soc. Perkin Trans. 1 1975, 1421; K. Ochi et al., ibid. 1979, 165. Pharmacology: T. Matsunaga et al., J. Dermatol. 17, 135 (1990). Clinical evaluation in psoriasis: M. J. P. Gerritsen et al., Br. J. Dermatol. 131, 57 (1994). Review: M. Nishimura et al., Eur. J. Dermatol. 3, 255-261 (1993).
Properties
White solid. uv max (ethanol): 265 nm.Therapeutic Category
Antipsoriatic.
Keywords
Antipsoriatic