9035. Talastine

Nomenclature

CAS number: 16188-61-7
2-[2-(Dimethylamino)ethyl]-4-(phenylmethyl)-1(2H)-phthalazinone; 4-benzyl-2-[2-(dimethylamino)ethyl]-1(2H)-phthalazinone.
C19H21N3O; mol wt 307.39.
C 74.24%, H 6.89%, N 13.67%, O 5.20%.

Description and references

Prepn: Engelbrecht et al., DE 1046625; eidem, US 3017411 (1958, 1962, both to VEB Deutsches Hydrierwerk Rodleben). Pharmacology: D. Lenke, Arzneim.-Forsch. 7, 678 (1957).

Chemical structure

Properties

Liquid, bp0.3 215-222°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 16188-76-4
HL-2186; Ahanon (Rodleben).
C19H21N3O.HCl; mol wt 343.85.
C 66.37%, H 6.45%, N 12.22%, O 4.65%, Cl 10.31%.

Properties

Crystals, mp 178°. LD50 i.p. in mice: 116 mg/kg (Lenke).

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Ethylenediamine Derivatives