Description and references

Broad spectrum, semi-synthetic glycopeptide antibiotic; inhibits bacterial cell wall formation and disrupts cell membrane integrity. Prepn: M. R. Leadbetter, M. S. Linsell, WO 0198328; eidem, US 6635618 (2001, 2003 both to Advanced Medicine). Chemistry and antibacterial properties: idem et al., J. Antibiot. 57, 326 (2004). Comparative in vitro antimicrobial activity: A. King et al., J. Antimicrob. Chemother. 53, 797 (2004). Mechanism of action study: D. L. Higgins et al., Antimicrob. Agents Chemother. 49, 1127 (2005). Clinical pharmacology: J. P. Shaw et al., Antimicrob. Agents Chemother. 49, 195 (2005). Clinical trial in complicated skin and soft-tissue infections: M. E. Stryjewski et al., Clin. Infect. Dis. 40, 1601 (2005). Review of discovery: J. K. Judice, J. L. Pace, Bioorg. Med. Chem. Lett. 13, 4165-4168 (2003); of clinical development: J. L. Pace, J. K. Judice, Curr. Opin. Investig. Drugs 6, 216-225 (2005).

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