Genetically engineered variant of human tissue plasminogen activator (t-PA), q.v.; expressed in Chinese hamster ovary cells. mol wt ≈65 kDa. Constructed by oligonucleotide-directed mutagenesis at 3 specific sites. Prepn: W. F. Bennett et al., WO 9324635 (1993 to Genentech); B. A. Keyt et al., Proc. Natl. Acad. Sci. USA 91, 3670 (1994). Pharmacology: C. R. Benedict et al., Circulation 92, 3032 (1995). Clinical pharmacokinetics: N. B. Modi et al., Thromb. Haemostasis 79, 134 (1998). Clinical trial in acute myocardial infarction: ASSENT-2 Investigators, Lancet 354, 716 (1999).
Thrombolytic.
Thrombolytic