9278. Thenaldine

Nomenclature

CAS number: 86-12-4
1-Methyl-N-phenyl-N-(2-thienylmethyl)-4-piperidinamine; 1-methyl-4-N-2-thenylanilinopiperidine; 1-methyl-4-amino-N-phenyl-N-(2-thenyl)piperidine; thenophenopiperidine; 1-methyl-4-[phenyl-(2-thenyl)amino]piperidine; thenalidine; Sandostene (Sandoz).
C17H22N2S; mol wt 286.43.
C 71.29%, H 7.74%, N 9.78%, S 11.19%.

Description and references

Prepn: Stoll, Bourquin, US 2717251 and US 2757175 (1955 and 1956 to Sandoz).

Chemical structure

Properties

bp0.02 158-160°, mp 95-97°.

Derivative

Tartrate.

Properties

Crystals, mp 170-172°.

Therapeutic Category

Tartrate as antihistaminic; antipruritic.

Keywords

Antihistaminic; Alkylamine Derivatives; Antipruritic