9299. Thiamiprine

Nomenclature

CAS number: 5581-52-2
6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purin-2-amine; 2-amino-6-[(1-methyl-4-nitroimidazol-5-yl)thio]purine; 2-amino-6-(1′-methyl-4′-nitro-5′-imidazolyl)mercaptopurine; Guaneran (Burroughs Wellcome).
C9H8N8O2S; mol wt 292.28.
C 36.98%, H 2.76%, N 38.34%, O 10.95%, S 10.97%.

Description and references

Prepd from thioguanine and 1-methyl-4-nitro-5-chloroimidazole: Hitchings, Elion, US 3056785 (1962 to Burroughs Wellcome).

Chemical structure

Properties

Crystals, dec slowly >200°. uv max: 320 nm at pH 1; 315 nm at pH 11.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Antimetabolites; Purine Analogs