9305. Thiazesim

Nomenclature

CAS number: 5845-26-1
5-[2-(Dimethylamino)ethyl]-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one; thiazenone; tiazesim.
C19H22N2OS; mol wt 326.46.
C 69.90%, H 6.79%, N 8.58%, O 4.90%, S 9.82%.

Description and references

Prepn of the hydrochloride: Krapcho et al., J. Med. Chem. 6(5), 544 (1963); Krapcho, US 3075967 (1963 to Olin Mathieson). Metabolism: J. Dreyfuss et al., J. Pharm. Sci. 57, 1497, 1505 (1968).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 3122-01-8
SQ-10496; Altinil (BMS).
C19H22N2OS.HCl; mol wt 362.92.
C 62.88%, H 6.39%, N 7.72%, O 4.41%, S 8.84%, Cl 9.77%.

Properties

Crystals from acetonitrile, mp 222-224°.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Bicyclics