9321. Thiobarbital

Nomenclature

CAS number: 77-32-7
5,5-Diethyldihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione; 5,5-diethyl-2-thiobarbituric acid; Ibition (IBI).
C8H12N2O2S; mol wt 200.26.
C 47.98%, H 6.04%, N 13.99%, O 15.98%, S 16.01%.

Description and references

Prepn: Fischer, Dilthey, Ann. 335, 350 (1904); Carrington, J. Chem. Soc. 1944, 124. Metabolism in man: Bush et al., J. Pharmacol. Exp. Ther. 134, 110 (1961).

Chemical structure

Properties

Pale yellow needles from water, mp 180°. Sol in about 88 parts hot water, in ethanol, chloroform, ether, acetone, ammonia, alkalies. Sparingly sol in toluene. Practically insol in benzene.

Therapeutic Category

Antihyperthyroid.

Keywords

Antihyperthyroid