9338. Thioguanosine

Nomenclature

CAS number: 85-31-4
2-Amino-6-mercapto-9-β-d-ribofuranosylpurine.
C10H13N5O4S; mol wt 299.31.
C 40.13%, H 4.38%, N 23.40%, O 21.38%, S 10.71%.

Description and references

Prepn: Fox et al., J. Am. Chem. Soc. 80, 1669 (1948).

Chemical structure

Derivative

Hemihydrate.

Properties

Tiny tapered prisms from water, dec 224-227°. [α]D22 64° (c = 1.3 in 0.1N NaOH). uv max (pH 4-6): 257, 342 nm (ε 8820, 24800). pKa 8.33.

Use

In cancer research, cf. 6-Mercaptopurine and Nebularine.