9370. Thiphenamil

Nomenclature

CAS number: 82-99-5
α-Phenylbenzeneethanethioic acid S-[2-(diethylamino)ethyl]ester; diphenylthioacetic acid S-(2-diethylaminoethyl) ester; diphenylthiolacetic acid 2-diethylaminoethyl ester; S-[2-(diethylamino)ethyl]diphenylthioacetate; β-diethylaminoethyl diphenylthioacetate.
C20H25NOS; mol wt 327.48.
C 73.35%, H 7.69%, N 4.28%, O 4.89%, S 9.79%.

Description and references

Smooth muscle relaxant. Prepn: Richardson, US 2390555 (1945 to Wm. P. Poythress); Clinton, US 2510773 (1950 to Sterling Drug); Richardson, J. Pharm. Sci. 55, 1316 (1966). Mechanism of action study: Y. Kimoto et al., J. Urol. 144, 1497 (1990). Clinical evaluation in detrusor incontinence: C. E. Constantinou, Urol. Int. 48, 42 (1992).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 548-68-5
Trocinate (Poythress).
C20H25NOS.HCl; mol wt 363.94.
C 66.00%, H 7.20%, N 3.85%, O 4.40%, S 8.81%, Cl 9.74%.

Properties

Rosettes of tiny needles from benzene + petr ether, large prisms from abs ethanol + ethyl acetate, mp 129-130°. Sol in water. Aq solns are about neutral to litmus.

Therapeutic Category

Antispasmodic.