9379. Thozalinone

Nomenclature

CAS number: 655-05-0
2-(Dimethylamino)-5-phenyl-4(5H)-oxazolone; 2-(dimethylamino)-5-phenyl-2-oxazolin-4-one; 5-phenyl-2-(dimethylamino)-2-oxazolin-4-one; tozalinone; Stimsen (Lederle).
C11H12N2O2; mol wt 204.23.
C 64.69%, H 5.92%, N 13.72%, O 15.67%.

Description and references

Prepn: Hardy, Jr. et al., US 3037990 (1962 to Am. Cyanamid). Pharmacological studies: B. M. Bernstein, C. N. Latimer, Psychopharmacologia 12, 338 (l968); U. H. Lindberg, J. Pedersen, Acta Pharm. Suec. 5, 15 (1968). In treatment of Parkinsonism: W. D. Gray, C. E. Edward, US 3665075 (1972 to Am. Cyanamid).

Chemical structure

Properties

Crystals from water, mp 133-136°.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant