9423. Tiaprost

Nomenclature

CAS number: 71116-82-0
7-[3,5-Dihydroxy-2-[3-hydroxy-4-(3-thienyloxy)-1-butenyl]cyclopentyl]-5-heptenoic acid; (15-R,S)-16-(3-thienyloxy)-ω-tetranor-PGF2α.
C20H28O6S; mol wt 396.50.
C 60.58%, H 7.12%, O 24.21%, S 8.09%.

Description and references

Analog of prostaglandin F2α, q.v. Prepn: W. Bartmann et al., DE 2524955 corresp to US 4258053 (1977, 1981 both to Hoechst); eidem, Prostaglandins 17, 301 (1979). Efficacy in bovine endometritis: W. Bentele et al., Tieraerztl. Umsch. 35, 676, 678, 683 (1980). Pharmacological effects: W. v. Rechenberg et al., Blue Book for the Vet. Profession (Hoechst AG) 30, 417 (1981). Administration in cattle: R. Humble, ibid. 425.

Chemical structure

Derivative

Tromethamine salt.

Nomenclature

Tiaprost trometamol; Iliren (Provet).
C24H39NO9S; mol wt 517.63.
C 55.69%, H 7.59%, N 2.71%, O 27.82%, S 6.19%.

Therapeutic Category (Veterinary)

Luteolytic.