9430. Ticrynafen

Nomenclature

CAS number: 40180-04-9
[2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid; [2,3-dichloro-4-(2-thenoyl)phenoxy]acetic acid; [2,3-dichloro-4-(2-thiophenecarbonyl)phenoxy]acetic acid; tienilic acid; thienylic acid; ANP-3624; CE-3624; SKF-62698; Diflurex (Anphar-Rolland); Selacryn (SKB).
C13H8Cl2O4S; mol wt 331.17.
C 47.15%, H 2.43%, Cl 21.41%, O 19.32%, S 9.68%.

Description and references

A heterocyclic derivative of phenoxyacetic acid. Prepn: J. Godfroid, J. Thuillier, DE 2048372; US 3758506 (1971, 1973 both to C.E.R.P.H.A.) and FR 2115042 (1972 to C.E.R.P.H.A.). Synthesis and pharmacology: G. Thuillier et al., Eur. J. Med. Chem. 9, 625 (1974). Pharmacokinetics in healthy volunteers: A. L. Kerremans et al., Eur. J. Clin. Pharmacol. 22, 515 (1982). Comparative study in hypertensive patients: B. T. Emmerson et al., ibid. 203. Hepatotoxicity study: J. W. Manier et al., Am. J. Gastroenterol. 77, 401 (1982).

Chemical structure

Properties

Crystals from 50% ethanol, mp 148-149°; also reported as mp 157°. LD50 in mice (mg/kg): 225 i.v., 1275 orally (US 3758506).

Therapeutic Category

Diuretic; uricosuric; antihypertensive.

Keywords

Antihypertensive; Diuretic; Uricosuric