9442. Timepidium Bromide

Nomenclature

CAS number: 35035-05-3
3-(Di-2-thienylmethylene)-5-methoxy-1,1-dimethylpiperidinium bromide; SA-504; Mepidium (Recordati); Sesden (Tanabe).
C17H22BrNOS2; mol wt 400.40.
C 50.99%, H 5.54%, Br 19.96%, N 3.50%, O 4.00%, S 16.02%.

Description and references

Anticholinergic. Prepn: M. Kawazu et al., DE 2128808 corresp to US 3764607 (1971, 1973 both to Tanabe). Pharmacological properties: H. Tamaki et al., Jpn. J. Pharmacol. 22, 685 (1972), C.A. 78, 52812 (1973). Metabolism: J. Sugihara, N. Taga, Radioisotopes 26, 238 (1977). Absorption, distribution, excretion: M. Yoshikawa, Oyo Yakuri 14, 179 (1977), C.A. 88, 163772 (1978). Teratological study: Y. Fujisawa et al., ibid. 7, 1293 (1973), C.A. 81, 99413 (1974). Chronic toxicity study: K. Doi et al., ibid. 13, 851 (1977), C.A. 88, 32014 (1978).

Chemical structure

Properties

Colorless cryst from acetone/ether, mp 198-200°.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic; Antimuscarinic