9443. Timiperone

Nomenclature

CAS number: 57648-21-2
4-[4-(2,3-Dihydro-2-thioxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone; 1-[1-[3-(4-fluorobenzoyl)propyl]-4-piperidyl]-2-mercaptobenzimidazole; 4-fluoro-4-[4-(2-thioxo-1-benzimidazolinyl)piperidino]butyrophenone; 1-[1-[3-(4-fluorobenzoyl)propyl]-4-piperidyl]-2,3-dihydrobenzimidazole-2-thione; DD-3480; Tolopelon (Daiichi).
C22H24FN3OS; mol wt 397.51.
C 66.47%, H 6.09%, F 4.78%, N 10.57%, O 4.02%, S 8.07%.

Description and references

Butyrophenone derivative with neuroleptic activity. Prepn: M. Sato et al., JP Kokai 75 84578; K. Ueno et al., US 3963727 (1975, 1976 both to Daiichi); M. Sato et al., J. Med. Chem. 21, 1116 (1978). Improved synthesis: M. Sato, M. Arimoto, Chem. Pharm. Bull. 30, 719 (1982). Pharmacology: T. Yamasaki et al., Jpn. J. Pharmacol. 27 (Suppl.), 124P (1977); eidem, Arzneim.-Forsch. 31, 701, 707 (1981); T. Shibuya et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 20, 251 (1982). Pharmacokinetics and metabolism: H. Tachizawa et al., Drug Metab. Dispos. 9, 442 (1981); K. Sudo et al., Xenobiotica 11, 685 (1981). Multicenter controlled clinical trials in schizophrenia: R. Takahashi et al., J. Int. Med. Res. 10, 257 (1982); T. Kariya et al., ibid. 11, 66 (1983).

Chemical structure

Properties

Crystals from acetone, mp 201-203°. uv max (ethanol): 226.5, 246, 309 nm. Slightly sol in water. LD50 in male rats, mice (mg/kg): 232, 478 orally (Yamasaki).

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Butyrophenones