9451. Tioclomarol

Nomenclature

CAS number: 22619-35-8
3-[3-(4-Chlorophenyl)-1-(5-chloro-2-thienyl)-3-hydroxypropyl]-4-hydroxy-2H-1-benzopyran-2-one; 3-[5-chloro-α-(p-chloro-β-hydroxyphenethyl)-2-thenyl]-4-hydroxycoumarin; Apegmone (Lipha).
C22H16Cl2O4S; mol wt 447.33.
C 59.07%, H 3.61%, Cl 15.85%, O 14.31%, S 7.17%.

Description and references

Slow-acting anticoagulant, related structurally to warfarin, q.v. Prepn: E. Boschetti et al., ZA 6707267 corresp to US 3574234 (1968, 1971 both to Lipha). Synthesis and anticoagulant activity: eidem, Chim. Ther. 7, 20 (1972).

Chemical structure

Properties

White cryst from methanol, mp 104°.

Therapeutic Category

Anticoagulant.

Keywords

Anticoagulant