9455. Tioxidazole

Nomenclature

CAS number: 61570-90-9
(6-Propoxy-2-benzothiazolyl)carbamic acid methyl ester; methyl 6-propoxy-2-benzothiazolylcarbamate; Sch-21480; Tiox (Schering-Plough).
C12H14N2O3S; mol wt 266.32.
C 54.12%, H 5.30%, N 10.52%, O 18.02%, S 12.04%.

Description and references

Structurally related to benzimidazole anthelmintics. Prepn and anthelmintic activity: M. M. Nafissi-Varchei, BE 840945; US 4006242 (1976, 1977 both to Schering). Physical data, activity against roundworms: E. Panitz et al., Experientia 34, 733 (1978). Anthelmintic effect against gastrointestinal parasites in naturally infected horses: J. H. Drudge et al., Am. J. Vet. Res. 41, 1383 (1980); E. T. Lyons et al., ibid. 42, 1048 (1981).

Chemical structure

Properties

White odorless solid, mp 178-180°. Insoluble in water. Slightly sol in organic solvents.

Therapeutic Category (Veterinary)

Anthelmintic for horses.