9513. Tolfenamic Acid

Nomenclature

CAS number: 13710-19-5
2-[(3-Chloro-2-methylphenyl)amino]benzoic acid; N-(3-chloro-o-tolyl)anthranilic acid; N-(2-methyl-3-chlorophenyl)anthranilic acid; GEA-6414; Clotam (GEA); Tolfedine (Vétoquinol); Tolfine (Vétoquinol).
C14H12ClNO2; mol wt 261.70.
C 64.25%, H 4.62%, Cl 13.55%, N 5.35%, O 12.23%.

Description and references

Deriv of anthranilic acid, related structurally to mefenamic and flufenamic acids, q.q.v. Prepn: NL 6600251 (1966 to Gea A/S), C.A. 66, 2377 (1967); R. A. Scherrer, F. W. Short, US 3313848 (1967 to Parke, Davis). Inhibition of prostaglandin biosynthesis: I. B. Linden et al., Scand. J. Rheumatol. 5, 129 (1976). HPLC determn: F. Nielsen-Kudsk, Acta Pharmacol. Toxicol. 47, 267 (1980). Metabolism: T. Kuninaka et al., Yakugaku Zasshi 101, 232 (1981), C.A. 95, 168 (1981). Human pharmacokinetics: P. Pentikaeinen et al., Eur. J. Clin. Pharmacol. 19, 359 (1981). Pharmacological studies: S. Yamashita et al., Toho Igakkai Zasshi 28, 76-105 (1981), C.A. 95, 16183, 180846 (1981). Clinical study: V. Rejholec et al., Scand. J. Rheumatol. Suppl. 33, 50 (1980); Suppl. 36, 1 (1980).

Chemical structure

Properties

Crystals from abs ethanol, mp 207-207.5°.

Therapeutic Category

Anti-inflammatory; analgesic.

Therapeutic Category (Veterinary)

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Aminoarylcarboxylic Acid Derivatives; Analgesic; Non-opioids; Anthranilic Acid Derivatives