9523. Tolpropamine

Nomenclature

CAS number: 5632-44-0
N,N,4-Trimethyl-γ-phenylbenzenepropanamine; N,N-dimethyl-3-phenyl-3-p-tolylpropylamine; 3-dimethylamino-1-phenyl-1-p-tolylpropane.
C18H23N; mol wt 253.38.
C 85.32%, H 9.15%, N 5.53%.

Description and references

Prepn: Bockmühl, Stein, DE 925468 (1955 to Hoechst); Klosa, J. Prakt. Chem. 34, 312 (1966). Pharmacology: Sendrail, Gleizes, Therapie 15, 119 (1960).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

Pragman Gelee (Milanfarma).
C18H23N.HCl; mol wt 289.84.
C 74.59%, H 8.35%, N 4.83%, Cl 12.23%.

Properties

mp 182-184°.

Therapeutic Category

Topical antihistaminic, antipruritic.

Keywords

Antihistaminic; Alkylamine Derivatives; Antipruritic