Murine monoclonal antibody targeted against CD-20 antigen located on mature B lymphocytes but not on normal stem cells or progenitor cells. 131Iodine radioimmunoconjugate designed for tumor-targeted treatment of non-Hodgkin's lymphoma (NHL). Prepn: M. S. Kaminski et al., US 5595721 (1997 to Coulter); and clinical evaluation: idem et al., N. Engl. J. Med. 329, 459 (1993). Clinical study of radioimmunotherapy in NHL: eidem, Blood 96, 1259 (2000). Review of mechanism of action and clinical application: A. K. Gopal, O. W. Press, J. Lab. Clin. Med. 134, 445 (1999); of use in follicular lymphoma: A. J. Davies, Expert Opin. Biol. Ther. 5, 577-588 (2005).
Antineoplastic.
Tositumomab 131I: Antineoplastic; Monoclonal Antibodies; Antineoplastic (Radiation Source)