9573. Tranylcypromine

Nomenclature

CAS number: 155-09-9
(1R,2S)-rel-2-Phenylcyclopropanamine; SKF-385.
C9H11N; mol wt 133.19.
C 81.16%, H 8.32%, N 10.52%.

Description and references

Monoamine oxidase inhibitor. Prepn: Burger, Yost, J. Am. Chem. Soc. 70, 2198 (1948); R. E. Tedeschi, US 2997422 (1961 to SK & F).

Chemical structure

Properties

Liquid, bp1.5-1.6 79-80°.

Derivative

Hydrochloride.
C9H11N.HCl; mol wt 169.65.
C 63.72%, H 7.13%, N 8.26%, Cl 20.90%.

Properties

Crystals from ethyl acetate + ether, mp 164-166°.

Derivative

Sulfate.

Nomenclature

CAS number: 13492-01-8
Parnate (GSK); Tylciprine (Théraplix).
(C9H11N)2.H2SO4; mol wt 364.46.
C 59.32%, H 6.64%, N 7.69%, S 8.80%, O 17.56%.

Properties

Crystals, sol in water; very slightly sol in alcohol, ether. Practically insol in chloroform.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Monoamine Oxidase Inhibitor