9587. Tretoquinol

Nomenclature

CAS number: 21650-42-0
1,2,3,4-Tetrahydro-1-[(3,4,5-trimethoxyphenyl)methyl]-6,7-isoquinolinediol; 1-(3′,4′,5′-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; trimethoquinol.
C19H23NO5; mol wt 345.39.
C 66.07%, H 6.71%, N 4.06%, O 23.16%.

Description and references

Synthesis of dl-form: Yamato et al., Tetrahedron Suppl. 8, 129 (1966). Pharmacology: Fogelman, Grundy, Br. J. Pharmacol. 38, 416 (1970). Metabolic studies: Meshi et al., Biochem. Pharmacol. 19, 2937 (1970); Satoh et al., Chem. Pharm. Bull. 19, 667 (1971).

Chemical structure

Derivative

dl-Form hydrochloride.

Nomenclature

CAS number: 18559-63-2

Properties

Pale yellow crystals from methanol + ether, decomp 224.5-226°.

Derivative

l-Form hydrochloride.

Nomenclature

CAS number: 18559-59-6
AQ-110; Inolin (Tanabe Seiyaku); Vems (Searle).
C19H23NO5.HCl; mol wt 381.85.
C 59.76%, H 6.34%, N 3.67%, O 20.95%, Cl 9.28%.

Properties

Pale yellow crystals, freely sol in water; sol in alcohol.

Therapeutic Category

Bronchodilator.

Keywords

β-Adrenergic Agonist; Bronchodilator