9638. 2,2,2-Trichloroethanol

Nomenclature

CAS number: 115-20-8
Trichloroethyl alcohol.
C2H3Cl3O; mol wt 149.40.
C 16.08%, H 2.02%, Cl 71.19%, O 10.71%.
CCl3CH2OH.

Description and references

Prepd by reduction of the corresponding ester, acid chloride, or acid with lithium aluminum hydride: Sroog et al., J. Am. Chem. Soc. 71, 1710 (1949). Manufacture by reduction of chloral hydrate with an amine borane: Chamberlain, Schechter, US 2898379 (1959 to Callery Chem.). Pharmacology: H. Molitor, H. Robinson, Curr. Res. Anesth. Analg. 17, 258 (1938).

Properties

Hygroscopic liquid, ethereal odor. At low temps it crystallizes in rhombic tablets. mp at 18°; bp 151-153°; d2020 1.55. Sol in about 12 parts water; miscible with alcohol or ether. pH of aq soln is 5-6, but on prolonged contact with water some free acid is formed. Keep well closed and protected from light.

Therapeutic Category

Sedative; hypnotic.

Keywords

Sedative/Hypnotic; Alcohols