9643. 2,4,5-Trichlorophenol

Nomenclature

CAS number: 95-95-4
Collunosol; Dowicide 2 (Dow).
C6H3Cl3O; mol wt 197.45.
C 36.50%, H 1.53%, Cl 53.87%, O 8.10%.

Description and references

Prepd by treating 1,2,4,5-tetrachlorobenzene with methanolic NaOH in autoclave at 160° for several hrs: Harrison et al., J. Chem. Soc. 1943, 235; Agfa, DE 411052 (1925); Chem. Zentralbl. 1925, I, 2411. Toxicity data: Deichmann, Fed. Proc. 2, 76 (1943). Review of toxicology and human exposure: Toxicological Profile for Chlorophenols (PB99-166639, 1999) 260 pp.

Chemical structure

Properties

Needles from alcohol or ligroin. Strong phenolic odor. mp 67°. Sublimes. bp746 248°. bp760 253°. Weak monobasic acid. pK (25°) 7.37. Soly (g/100 g of solvent at 25°): acetone 615; benzene 163; carbon tetrachloride 51; ether 525; denatured alcohol formula 30, 525; methanol 615; liquid petrolatum (at 50°) 56; soybean oil 79; toluene 122; water <0.2. LD50 orally in rats: 0.82 g/kg (Deichmann).

Derivative

Sodium salt sesquihydrate.

Nomenclature

Dowicide B (Dow).

Description and references

Prepn: US 1991329 (1935 to Dow).

Properties

Flakes. Solubility (g/100 g solvent at 25°); acetone 163; denatured alcohol formula 30, 186; ethylene glycol 33; methanol 241; water 113. pH of satd aq soln 11.0-13.0.

Use

Fungicide, bactericide, biocide; intermediate in production of herbicides.