9679. Trifluomeprazine

Nomenclature

CAS number: 2622-37-9
N,N,β-Trimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine; 10-[3-(dimethylamino)-2-methylpropyl]-2-(trifluoromethyl)phenothiazine; RP-7746.
C19H21F3N2S; mol wt 366.44.
C 62.28%, H 5.78%, F 15.55%, N 7.64%, S 8.75%.

Description and references

Prepn: GB 813861 corresp to G. E. Ullyot, US 2921069 (1959, 1962 both to SK&F). Metabolism study: T. L. Flanagan et al., J. Pharm. Sci. 51, 996 (1962). Chromatographic studies: M. W. Anders, G. J. Mannering, J. Chromatogr. 7, 258 (1962); R. J. Warren et al., J. Pharm. Sci. 55, 144 (1966); B. B. Wheals, J. Chromatogr. 187, 65 (1980). Pharmacological studies: R. C. Kelsey, G. J. Frishmuth, Arch. Int. Pharmacodyn. Ther. 173, 44 (1968); E. W. Baur, J. Pharmacol. Exp. Ther. 177, 219 (1971).

Chemical structure

Properties

uv max (95% ethanol): 308, 258 nm (log ε 3.60, 4.55).

Derivative

Maleate.

Nomenclature

Nortran (Norden).
C19H21F3N2S.C4H4O4; mol wt 482.52.
C 57.25%, H 5.22%, F 11.81%, N 5.81%, S 6.65%, O 13.26%.

Therapeutic Category (Veterinary)

Tranquilizer.