9708. Trimethobenzamide

Nomenclature

CAS number: 138-56-7
N-[(2-Dimethylaminoethoxy)benzyl]-3,4,5-trimethoxybenzamide; 4-(2-dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl)benzylamine.
C21H28N2O5; mol wt 388.46.
C 64.93%, H 7.27%, N 7.21%, O 20.59%.

Description and references

Prepn: M. W. Goldberg, S. Teitel, US 2879293 (1959 to Hoffmann-La Roche). Pharmacology: K. W. Blessel et al., Anal. Profiles Drug Subs. 2, 551-570 (1973).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 554-92-7
Ro-2-9578; Anaus (Molteni); Tigan (SKB); Xametina (Zambeletti).
C21H28N2O5.HCl; mol wt 424.92.
C 59.36%, H 6.88%, N 6.59%, O 18.83%, Cl 8.34%.

Properties

Crystals, mp 187.5-190°. Freely sol in water (approx soly at 25° >50%). A 5% aq soln is stable to autoclaving at 120° for 20 min at pH 3-7.

Therapeutic Category

Antiemetic.

Keywords

Antiemetic