9737. Tripamide

Nomenclature

CAS number: 73803-48-2
(3aα,4α,7α,7aα)-3-(Aminosulfonyl)-4-chloro-N-(octahydro-4,7-methano-2H-isoindol-2-yl)benzamide; 4-chloro-N-(endo-hexahydro-4,7-methanoisoindolin-2-yl)-3-sulfamoylbenzamide; toripamide; ADR-033; E-614; Normonal (Eisai).
C16H20ClN3O3S; mol wt 369.87.
C 51.96%, H 5.45%, Cl 9.59%, N 11.36%, O 12.98%, S 8.67%.

Description and references

Sulfonamide with diuretic and peripheral vasodilator activity. Prepn: H. Hamano et al., JP 73 5585 (1973 to Eisai), C.A. 78, 136070r (1973). Synthesis of 14C-tripamide: T. Nakamura et al., J. Labelled Compd. Radiopharm. 14, 191 (1978). Pharmacological study: T. Satoh et al., Oyo Yakuri 21, 607 (1981), C.A. 96, 28414u (1982). Metabolism: T. Horie et al., Xenobiotica 11, 197, 693 (1981).

Chemical structure

Properties

Colorless needles.

Therapeutic Category

Antihypertensive; diuretic.

Keywords

Antihypertensive; Sulfonamide Derivatives; Diuretic; Sulfonamide Derivatives