9770. Troleandomycin

Nomenclature

CAS number: 2751-09-9
Oleandomycin triacetate ester; triacetyloleandomycin; NSC-108166; Cyclamycin (Wyeth); Wytrion (Wyeth); Evramycin (Wyeth); TAO (Roerig); Triocetin (OFF).
C41H67NO15; mol wt 813.97.
C 60.50%, H 8.30%, N 1.72%, O 29.48%.

Description and references

Semi-synthetic macrolide antibiotic. Prepd from oleandomycin: Celmer et al., Antibiot. Annu. 1957-1958, p 476; GB 877730 (1958 to Pfizer); M. Khristov, N. Petkov, Farmatsiya (Sofia) 27, 1 (1977), C.A. 90, 23458c (1979). Review: S. Ross, Antimicrobial Therapy, B. M. Kagan, Ed. (Saunders, Philadelphia, 1970) pp 134-144.

Chemical structure

Properties

Crystals from isopropanol. Practically tasteless. Dec 176°. [α]D25 23° (methanol). pKa 6.6. Soly in water <0.1 g/100 ml.

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Antibiotics); Macrolides