9771. Tromantadine

Nomenclature

CAS number: 53783-83-8
2-[2-(Dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-ylacetamide; N-1-adamantyl-N-[2-(dimethylamino)ethoxy]acetamide; 1-(dimethylaminoethoxyacetamido)adamantane.
C16H28N2O2; mol wt 280.41.
C 68.53%, H 10.06%, N 9.99%, O 11.41%.

Description and references

Prepn: Scherm, Peteri, DE 1941218 (1971 to Merz), C.A. 74, 99516k (1971); May, Peteri, Arzneim.-Forsch. 23, 718 (1973). Chemistry and toxicology: Peteri, Sterner, ibid. 577.

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 41544-24-5
D-41; Viru-Merz (Merz); Viruserol (Zyma).
C16H28N2O2.HCl; mol wt 316.87.
C 60.65%, H 9.22%, N 8.84%, O 10.10%, Cl 11.19%.

Properties

Crystals, mp 157-158°. LD50 orally in rats: 630 mg/kg; i.v. in mice: 71.0 mg/kg (Peteri, Sterner).

Therapeutic Category

Antiviral.

Keywords

Antiviral; Adamantanes