9794. Tryparsamide

Nomenclature

CAS number: 554-72-3
[4-[(2-Amino-2-oxoethyl)amino]phenyl]arsonic acid monosodium salt; N-(carbamoylmethyl)arsanilic acid monosodium salt; monosodium N-phenylglycinamide-p-arsonate; Glyphenarsine; Tryparsone; Tryponarsyl; Trypothane.
C8H10AsN2NaO4; mol wt 296.09.
C 32.45%, H 3.40%, As 25.30%, N 9.46%, Na 7.76%, O 21.61%.

Description and references

Prepd by heating a soln of arsanilic acid in aq NaOH, Na2CO3 and chloroacetamide: Jacobs, Heidelberger, J. Am. Chem. Soc. 41, 1590 (1919); Org. Synth. 8, 100 (1928). US 1280119; US 1280124; US 1280126 (1918); US 2465308 (1949).

Chemical structure

Derivative

Hemihydrate.

Properties

Platelets, slowly affected by light, stable to air. One gram dissolves in about 2 ml water. Slightly sol in alcohol. Insol in ether, chloroform. pH of 1:20 aq soln 6.5. Keep tryparsamide in tight containers, preferably at a temp not above 20° and protected from light.

Therapeutic Category

Antiprotozoal (Trypanosoma).

Keywords

Antiprotozoal (Trypanosoma)