9833. Tyloxapol
Nomenclature
CAS number: 25301-02-4
4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde
and oxirane; oxyethylated tertiary octylphenol formaldehyde polymer; p-isooctylpolyoxyethylenephenol formaldehyde polymer; tyloxypal; Alevaire (Sanofi Winthrop); Superinone (Sanofi Winthrop); Triton A-20 (Rohm & Haas); Triton WR-1339 (Rohm & Haas). Description and references
Nonionic detergent with surface-tension-reducing properties. Prepn: Bock, Rainey, US 2454541 (1948 to Rohm & Haas); J. W. Cornforth et al., Nature 168, 150 (1951). Use to induce exptl hyperlipidemia: A. Kellner et al., J. Exp. Med. 93, 373 (1951); P. E. Schurr et al., Lipids 7, 68 (1972). Use as ophthalmic excipient: D. E. Guttman et al., J. Pharm. Sci. 50, 305 (1961). Phase behavior of mixtures with water: K. Westesen, Int. J. Pharm. 102, 91 (1994); K. Westesen, M. H. J. Koch, ibid. 103, 225 (1994). Tissue distribution and excretion: R. L. DeAngelis et al., Xenobiotica 25, 521 (1995).
Properties
d20 1.0963. Cloud point: 92-97°. Slowly but freely misc with water. Sol in benzene, toluene, chloroform, carbon tetrachloride, carbon disulfide, acetic acid. Alkaline pH. Oxidized by metals.Derivative
Combination with colfosceril palmitate and hexadecanol see Exosurf.Use
Pharmaceutic aid (dispersing agent; excipient). To induce exptl hyperlipidemia in animal models.Therapeutic Category
Mucolytic.
Keywords
Mucolytic