9914. Valpromide

Nomenclature

CAS number: 2430-27-5
2-Propylpentanamide; 2-propylvaleramide; 2-propylpentamide; dipropylacetamide; Depamide (Sanofi).
C8H17NO; mol wt 143.23.
C 67.08%, H 11.96%, N 9.78%, O 11.17%.

Description and references

Prodrug of valproic acid, q.v. Prepn: E. Fischer, A. Dilthey, Ber. 35, 844 (1902); M. Tiffeneau, Y. Deux, Compt. Rend. 212, 105 (1941). GC determn in plasma: M. Pokrajac et al., Pharm. Acta Helv. 67, 237 (1992). Review of pharmacology and clinical activity: M. Bialer, Clin. Pharmacokinet. 20, 114-122 (1991).

Chemical structure

Properties

White, odorless and bitter crystalline powder, mp 125-126°. Practically insol in water.

Therapeutic Category

Anticonvulsant.

Keywords

Anticonvulsant