9934. Vapreotide

Nomenclature

CAS number: 103222-11-3
d-Phenylalanyl-l-cysteinyl-l-tyrosyl-d-tryptophyl-l-lysyl-l-valyl-l-cysteinyl-l-tryptophanamide cyclic (2→7)-disulfide; BMY-41606; RC-160; Octastatin (Debiopharm).
C57H70N12O9S2; mol wt 1131.37.
C 60.51%, H 6.24%, N 14.86%, O 12.73%, S 5.67%.

Description and references

Octapeptide somatostatin analog. Prepn: A. V. Schally, R. Z. Cai, EP 203031 (1986 to Tulane); eidem, US 4650787 (1987). Inhibition of growth hormone, insulin and glucagon release: T. Karashima et al., Life Sci. 41, 1011 (1987); on pancreatic secretion: S. J. Konturek et al., Proc. Soc. Exp. Biol. Med. 187, 241 (1988). RIA determn in serum: M. Mason-Garcia et al., Proc. Natl. Acad. Sci. USA 85, 5688 (1988). Clinical pharmacology: M. A. Ritz et al., Br. J. Clin. Pharmacol. 47, 195 (1999). Clinical trial for variceal bleeding in cirrhosis: P. Calès et al., N. Engl. J. Med. 344, 23 (2001).

Chemical structure

Therapeutic Category

Hemostatic.

Keywords

Hemostatic; Somatostatin Analog