9980. Viloxazine

Nomenclature

CAS number: 46817-91-8
2-[(2-Ethoxyphenoxy)methyl]morpholine; 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine; ICI-58834.
C13H19NO3; mol wt 237.29.
C 65.80%, H 8.07%, N 5.90%, O 20.23%.

Description and references

Prepn: K. B. Mallion et al., GB 1138405; eidem, US 3714161 (1969, 1973 both to I.C.I.). Manufacturing process: S. A. Lee, GB 1260886; idem, US 3712890 (1972, 1973 both to I.C.I.). Pharmacology: Mallion et al., Nature 238, 157 (1972); Bereen, Lancet 1, 379 (1973). Toxicity: R. D. Brosnan et al., J. Int. Med. Res. 4, 83 (1976). Clinical evaluation in narcolepsy: C. Guilleminault et al., Sleep 9, 275 (1986). Review of pharmacology and therapeutic efficacy: R. M. Pinder et al., Drugs 13, 401 (1977).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 35604-67-2
Vivalan (Zeneca); Vicilan (Zeneca); Vivarint (Zeneca).
C13H19NO3.HCl; mol wt 273.76.
C 57.04%, H 7.36%, N 5.12%, O 17.53%, Cl 12.95%.

Properties

mp 185-186°. LD50 in mice (mg/kg): 1000 orally, 60 i.v. (Brosnan).

Therapeutic Category

Antidepressant.

Keywords

Antidepressant