Description and references

Serotonin 5HT_1A-receptor agonist; enhances production of neurotrophic factors and extends motor neuron survival. Prepn: D. Nisato et al., EP 101381; eidem, US 4521428 (1984, 1985 both to Sanofi); of radiolabelled compound: N. Robic, J.-P. Nol, J. Labelled Compd. Radiopharm. 42, 109 (1999). Pharmacology and receptor binding: L. Cervo et al., Eur. J. Pharmacol. 253, 139 (1994). Effect on neuron survival: Y. Iwasaki et al., J. Neurol. Sci. 160, Suppl. 1, S92 (1998). Neuroprotective effect in animal model of multiple sclerosis: B. Bourrié et al., Proc. Natl. Acad. Sci. USA 96, 12855 (1999). Review of pharmacology and clinical potential in treatment of amyotrophic lateral sclerosis: J. Fournier et al., CNS Drug Rev. 3, 148-167 (1997).

Derivative