Description and references

β₁-Adrenoceptor partial agonist. Prepn: BE 867376; B. G. Main, J. J. Barlow, US 4143140 (1978, 1979 both to ICI); prepn and adrenoceptor stimulant activity: J. J. Barlow et al., J. Med. Chem. 24, 315 (1981). Cardiovascular activity: A. Nuttall, H. M. Snow, Br. J. Pharmacol. 77, 381 (1982). Hemodynamics, cardioselectivity and kinetics: G. Jennings et al., Clin. Pharmacol. Ther. 35, 594 (1984). Hemodynamic effects: J.-M. R. Detry et al., Eur. Heart J. 4, 584 (1983); H. Sato et al., Circulation 75, 213 (1987). Metabolism: T. R. Marten et al., Drug Metab. Dispos. 12, 652 (1984). HPLC determn in biological fluids: C. J. Oddie et al., J. Chromatogr. 308, 370 (1984). Clinical evaluations: F. L. Tseu et al., Br. Heart J. 56, 469 (1986); L. Barrios et al., Eur. J. Clin. Pharmacol. 29, 667 (1986). Clinical comparison with atenolol, q.v., in asthmatic patients: J. W. J. Lammers et al., Br. J. Clin. Pharmacol. 22, 595 (1986).

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