10078. Ximoprofen

Nomenclature

CAS number: 56187-89-4
4-[3-(Hydroxyimino)cyclohexyl]-α-methylbenzeneacetic acid; p-(3-oxocyclohexyl)hydratropic acid oxime; XIFAM; 2-[4-(3-oximinocyclohexyl)phenyl]propionic acid; 13832-JL.
C15H19NO3; mol wt 261.32.
C 68.94%, H 7.33%, N 5.36%, O 18.37%.

Description and references

Nonsteroidal anti-inflammatory. Prepn: J. G. Maillard, DE 2442910; idem, US 3935255 (1975, 1976 both to Lab. Jacques Logeais). Metabolism: B. C. Mayo et al., Xenobiotica 20, 233 (1990). Clinical pharmacokinetics: I. W. Taylor et al., Br. J. Clin. Pharmacol. 32, 242 (1991). GC determn in plasma: I. W. Taylor, L. F. Chasseaud, J. Chromatogr. 495, 275 (1989). HPLC determn in urine: G. R. Morris et al., ibid. 530, 377 (1990). Clinical evaluation: M. Dougados et al., J. Rheumatol. 16, 1167 (1989).

Chemical structure

Properties

Crystals from water/methanol, mp 178°.

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives