10079. Xipamide

Nomenclature

CAS number: 14293-44-8
4-Chloro-5-sulfamoyl-2′,6′-salicyloxylidide; 4-chloro-2′,6′-dimethyl-5-sulfamoylsalicylanilide; 4-chloro-5-sulfamylsalicyloyl-2′,6′-dimethylanilide; Bei-1293; Aquaphor (Lilly); Chronexan (Viatris); Diurexan (Viatris); Lumitens (Solvay).
C15H15ClN2O4S; mol wt 354.81.
C 50.78%, H 4.26%, Cl 9.99%, N 7.90%, O 18.04%, S 9.04%.

Description and references

Salicylic acid derivative. Prepn: NL 6607680; Liebenow, US 3567777 (1966, 1970 both to P. Beiersdorf). Clinical studies: O. Hammer, U. Dembowski, Med. Klin. 64, 1862 (1969); R. Fischer, A. Lenhartz, Med. Welt 1970, 270. Review of pharmacology and therapeutic efficacy: B. N. C. Prichard, R. N. Brogden, Drugs 30, 313-332 (1985).

Chemical structure

Properties

Crystals from methanol-water, mp 256°.

Therapeutic Category

Diuretic; antihypertensive.

Keywords

Antihypertensive; Sulfonamide Derivatives; Diuretic; Sulfonamide Derivatives