Description and references

Serotonin uptake inhibitor. Prepn: P. B. Berntsson et al., ZA 7201503; eidem, US 3928369 (1972, 1975 both to AB Hassle). X-ray crystallographic study: S. Abrahamsson et al., Acta Chem. Scand. A30, 609 (1976). In vivo study in rats and humans: S. B. Ross et al., Life Sci. 19, 205 (1976). Pharmacokinetics: D. Brown, Eur. J. Clin. Pharmacol. 17, 111 (1980). Mode of action: K. Fuxe et al., Neurosci. Lett. 13, 307 (1979). Metabolism: J. Lundstrm et al., Arzneim.-Forsch. 31, 486 (1981). Clinical studies: A. Georgotas et al., Am. J. Psychiatry 139, 1057 (1982); E. Syvalahti et al., J. Int. Med. Res. 10, 250 (1982). Profile of antidepressant action: S. A. Montgomery et al., Adv. Biochem. Psychopharmacol. 32, 35 (1982). Reversal of ethanol-induced memory impairment in human subjects: H. Weingartner et al., Science 221, 472 (1983). Review of pharmacology and therapeutic efficacy: R. C. Heel et al., Drugs 24, 169-206 (1982). Symposium on pharmacology, pharmacokinetics, metabolism, clinical studies: Br. J. Clin. Pract. 1982, Suppl. 19, 1-122.

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