10170. Zipeprol

Nomenclature

CAS number: 34758-83-3
4-(2-Methoxy-2-phenylethyl)-α-(methoxyphenylmethyl)-1-piperazineethanol; α-(α-methoxybenzyl)-4-(β-methoxyphenethyl)-1-piperazineethanol; 1-(2-hydroxy-3-methoxy-3-phenylpropyl)-4-(2-methoxy-2-phenylethyl)piperazine; 1-(2-methoxy-2-phenylethyl)-4-(2-hydroxy-3-methoxy-3-phenylpropyl)piperazine.
C23H32N2O3; mol wt 384.51.
C 71.84%, H 8.39%, N 7.29%, O 12.48%.

Description and references

Prepn: R. Y. Mauvernay et al., DE 2109366; eidem, US 3718650 (1971, 1973 both to Mauvernay). Pharmacology: G. Rispat et al., Arzneim.-Forsch. 26, 523 (1976); D. Cosnier et al., ibid. 848. Clinical abuse potential: L. Janiri et al., Drug Alcohol Depend. 27, 121 (1991). GC-MS determn in plasma and urine: P. Kintz et al., J. Pharm. Biomed. Anal. 11, 335 (1993).

Chemical structure

Properties

Crystals from abs ethanol, mp 83°.

Derivative

Dihydrochloride.

Nomenclature

CAS number: 34758-84-4
CERM-3024; Antituxil-Z (Ghimas); Citizeta (CT); Mirsol (Permamed); Respirase (Gibipharma); Robnin (Nikken); Zitoxil (Lifepharma).
C23H32N2O3.2HCl; mol wt 457.43.
C 60.39%, H 7.49%, N 6.12%, O 10.49%, Cl 15.50%.

Properties

Crystals from abs ethanol, mp 231°. Very stable in aq soln. LD50 orally in mice: 301 mg/kg (Rispat).

Therapeutic Category

Antitussive.

Keywords

Antitussive