Description and references

Non-steroidal anti-inflammatory drug (NSAID). Prepn: J. R. Carson, DE 2102746; idem, US 3752826 (1971, 1973 both to McNeil); J. R. Carson, S. Wong, J. Med. Chem. 16, 172 (1973). Pharmacology: R. Sofia et al., Pharmacol. Res. Commun. 11, 179 (1979); P. O'Neill et al., J. Pharmacol. Exp. Ther. 209, 366 (1979). Determn in plasma by HPLC: K.-T. Ng, T. Snyderman, J. Chromatogr. 178, 241 (1979). Metabolism: J. M. Grindel et al., Drug Metab. Dispos. 8, 343 (1980); W. N. Wu et al., ibid. 349. Pharmacokinetics: R. K. Nayak et al., Clin. Pharmacol. Ther. 27, 395 (1980). Series of articles on pharmacology, kinetics, clinical studies: J. Clin. Pharmacol. 20, 213-424 (1980). Preclinical narcotic abuse liability evaluation: J. H. Woods et al., Arzneim.-Forsch. 33, 218 (1983). Multicenter clinical study in painful conditions: C. E. Steele, W. L. Jefferson, Curr. Med. Res. Opin. 8, 382 (1983). Review of pharmacology and therapeutic efficacy: P. A. Morley et al., Drugs 23, 250-275 (1982). Comprehensive description: M. Zinic et al., Anal. Profiles Drug Subs. 15, 673-698 (l986).

Properties

Derivative